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Last Year´s Workshops & Panels

Last Year´s Program

 

MONDAY, MARCH 5, 2007

Interactive Parallel Workshops
9:00-10:30
Biocatalysis – Biology Catalysing Chemistry – Does it Work?
Moderator:
Dr. Wolfgang Schoenfeld, CEO, EUCODIS GmbH
Panelists:
Dr. Simone Kardinahl, Microbiological Development and Process Development , Bayer Schering Pharma AG
Dr. Burghard Koenig, R&D Antiinfectives, Head Biocatalysis, Sandoz Industrial Products GmbH
Dr. Oliver May, Competence Manager Biocatalysis, DSM Pharmaceutical Products
Dr. Ming-Qiang Zhang, VP Research, Biotica Technology Limited
   
Abstract:

The use of biocatalytic processes is of fundamental importance in drug discovery and production of pharmaceuticals: Fermentation products - as starting molecules for further derivatisation or even final products - are well established in the industry from its very beginning. On the other hand, over years the use of biocatalytic steps to reduce costs and simplify large scale production is steadily growing.
 
However, there is still huge potential for biocatalytic application in pharmaceutical research as well as in production, if the gap can be bridged between high risky, innovative research using white biotech tools and low risk, cost driven production applications.
 
The panel will discuss the problems and perspectives of “white” biotech in “red” biotech:
Do biosynthetic modifications of synthetic pathways of complex natural compounds really work as a sustainable platform?
How to bring biocatalysis closer to chemical catalysis – the cross talk between chemists and biologists in chemistry? Competition versus synergy!
How to integrate biocatalytic processes early during the production development of novel APIs?

9:00-10:30
Financing Innovation - The View of Entrepreneurs and VCs
Moderator:
Ian Nicholson, CEO, Chroma Therapeutics
Panelists:
Joel Besse, Partner, Atlas Venture
Dr. Francesco De Rubertis, Partner Life Sciences, Index Ventures Management
Dr. Claudio Semeraro, CEO, Z-Cube srl
Dr. Francesco Sinigaglia, CEO, BioXell
   
Abstract:

Factors such as increasing R&D costs, competition, regulatory restrictions, access to patients and public pressure are collectively increasing the hurdles industry has to jump in order to bring drugs to the market in a time and cost effective manner.

In the past few years, the role of venture capitalists has morphed in response to industry developments. Biotech VCs traditionally invested in early-stage companies and nursed them along with advice and connections (and more cash!) with the intention of building them into a large drug-discovery company. Today it appears that this model is too “capital intensive” and may no longer be “affordable” by the venture capital industry.

There is a clear need for innovative business models in the biotech industry. Companies are exploring different options such as asset focused financing and project financing as alternative solutions for attractive business models.

Is there really a new business model “under development”? How can early-stage companies still attract investments? What are VCs today seeing as a good value proposition? This panel will explore how to finance innovation today.

   
9:00-10:30

Licensing and Strategic Alliances: How to Get Married and Avoid an Ugly Divorce

Moderator:
Dr. Ruediger Herrmann, Partner, Mayer Brown Rowe & Maw LLP
Panelists:
Prof. Gregor Cevc, CEO, IDEA AG
Dr. Rainer Kramer, VP Business Development, Jerini AG
Dr. Holger Reithinger, Partner, Global Life Science Ventures GmbH
Dr. Christoph Thierolf, VP Corporate Business Development/M&A, Fresenius AG
   
Abstract:

Licensing and Strategic Alliances include the potential for great financial and other benefit to the parties. However, just as in a perfect marriage, partners must fit to each other and be willing to accommodate to the other and its needs. The closer the relation the bigger the risks that the alliance goes sour and that it ends in a painful winding-up.

The panel will discuss its experiences of what is necessary for a successful Licensing and Strategic Alliance and what needs to be considered for choosing the right partner and the right form and structure of a strategic alliance. In the focus shall be issues such as: how do I successfully negotiate, where do cultural differences exist, why is management of the alliance important and what differentiates a successful management from a non-successful, when is an equity participation a wise tool and what other forms are recommendable to make the relationship with the partner “strategic” and what should be regulated for a situation of “quarrel” and, even worse, for “divorce”. The panel will discuss the topic from all sides and aspects, including business, financial, legal and cultural issues.

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9:00-10:30
A Different Perspective on Alliances: Leveraging Platform Technologies To Build Greater Value
Downstream
Moderator:
Dr. Ravi Kiron, President, RK Consulting
Panelists:
Martina Molsbergen, VP Business Development, BioWa, Inc.
Dr. Murali K. Prahalad, Director, Corporate Development, Invitrogen Corporation
Scott Salka , CEO, Ambit Biosciences
Dr. David Sourdive, COO, Corporate Development, Cellectis SA
   
Abstract:

Many early-stage biotech companies with strong discovery platforms often attempt to commercialize their technologies before they are market ready. The result is that they often do not get value for their innovation and fail to forge key alliances, are forced to accept poor terms or simply run out of cash.  This session will examine partnerships with traditional drug development firms as well as tools and service companies as an alternate means of adding value to a pre-clinical or early-stage portfolio. The panel features senior executives from companies with strong platform technologies that have forged strategic relationships with a variety of different firms. They will discuss their strategies for leveraging these relationships to build towards commercial success.

 
Welcome & Opening Remarks
10:45-11:30

Carola Schropp, Managing Partner, EBD Group

Filippo Penati, President, Province of Milan
•Ambassador Umberto Vattani, President, Italian Institute for Foreign Trade (ICE)

Dr. Roberto Gradnik, President of Assobiotec; Senior Executive VP, Merck Serono International, Commercial Europe

Dr. Sergio Dompé, President, Farmindustria

James C. Greenwood, President & CEO, Biotechnology Industry Organization (BIO)

Dr. Rolf Hoffmann, Senior VP, Amgen International

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Opening Plenary Session
11:30-12:30

Rethinking the Biotech-Pharma Partnering Model

Moderator:
Roger Longman, Managing Partner, Windhover Information
Panelists:
Robert Blum, President & CEO, Cytokinetics, Inc.
Dr. Judith Hills, Corporate and Business Development, VP, Licensing, Europe, Japan & Asia Pacific, Bristol-Myers Squibb
Louis Scotti, VP, Marketing and Business Development, Arena Pharmaceuticals, Inc.
Dr. Rob Wills, VP, Alliance Management, Johnson & Johnson
   
Abstract:

The upfront cash value of early- and late-stage biotech alliances, according to data from Windhover, has risen dramatically over the past three years.  But so has the value of non-cash components – marketing carve-outs, co-promotions, development direction.  And many of these deals are morphing into acquisitions -- $12 billion worth of biotech acquisitions in 2006, says Windhover, up by 20% over the previous year, with twice as many deals valued at greater than $400 million.  The driver: Big Pharma’s pipeline drought.  All of which has increased the challenge for Big Pharma’s dealmakers and the opportunities for biotechs.

This panel will talk about those challenges and opportunities: the new trade-offs Big Pharma is being forced to make (between internal and external spending; between old and new returns expectations); the new strategies for risk sharing and off-P&L financing; and fundamentally, the sustainability of ever-more expensive partnering in a high-infrastructure industry .  This session will feature several of the most experienced dealmakers from both Big Pharma and biotech. 


Panel Discussions
13:30-18:15
BUSINESS DEVELOPMENT TRACK
13:30-14:30
Biotech to Biotech Deals - How does Big Pharma look at these Collaborations?
Moderator:
Diane Romza-Kutz, Member of the Firm, Health Care and Life Sciences Practice, Epstein Becker & Green P.C.
Panelists:
Steven Damon, VP, Business Development, Altea Therapeutics
Pamela Demain, Executive Director, Corporate Licensing, Merck & Co., Inc.
Joseph Dillon, Senior VP, Corporate Development Services, The Mattson Jack Group
Michele Garufi, Chairman & CEO, NicOx SA
Dr. Don Lucas, Associate Director, Alliances, Licensing, and Acquisitions, Procter & Gamble Pharmaceuticals    
   
Abstract:

The trend has developed for biotech companies to do deals among each other in early-stage development phases.

Even though these collaborations can be very successful and support company development in its early years, their impact goes beyond the early-stage phase of companies.

Once companies increase in size, their platform/products prove to be promising and companies start partnering with larger multinationals for more global deals, those early-stage collaborations might pose obstacles to reach the next milestone in a biotech’s development.

How does Big Pharma view early-stage deals?  How can you best structure those collaborations? Where are mistakes most often made and how do you avoid them? 

This panel will provide an insight on this topic from the eye of Biotech as well as Big Pharma. Major dealmakers from both sides will shed light on the risks and chances of doing Biotech to Biotech early-stage deals.

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14:45-15:45
The Globalization of Dealmaking – What Is The Most Effective Strategy for Accessing Non-Traditional Markets and Resources?
Moderator:
Dr. Simba Gill, CEO, moksha8 and Venture Partner, Entrepreneur in Residence, TPG Growth
Panelists:
Robert DeBenedetto, VP Global Business Development, NovaQuest, The Partnering Group of Quintiles Transnational
Dr. Ken Macleod, Principal, Paul Capital Partners
Gardiner Smith, Advisor, SHI Link
Dr. Greg Wiederrecht, VP, External Scientific Affairs, Merck & Co., Inc.
   
Abstract:

While the U.S. and European drug development markets remain dominant in terms of size and number of companies, the rest of the world is beginning to catch up as investors and biotech entrepreneurs are figuring out how to leverage the cost and regulatory advantages found in emerging biotech hubs around the world. The more innovative companies are leaving the comfort zone of keeping everything close to home and are now looking for discovery and development partners in regions offering better service, comparable or better science, and more affordable prices. At the same time, the larger regional firms in Asia and other developing markets are looking to assert themselves globally by exploring innovative partnerships and development strategies to build value downstream and access markets in the U.S. and Europe.  Drug discovery, development, and distribution are all now global activities involving key stakeholders throughout the world.  This session will examine new types of transactions and alliances that seek to take advantage of opportunities to access capital, technology, markets, and drug development expertise on a global basis. Panelists will discuss why and how they have made these decisions to look beyond the traditional options for building companies and why they believe this will increase their prospects for success.

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16:00-17:00
Size iIsn’t Everything – Can Mid-Size Pharma Compete For The Best In-Licensing Opportunities?
Moderator:
Morrie Ruffin, CEO, Life Tech Innovations, LLC
Panelists:
Vincent Aurentz, Senior Executive VP, Portfolio Management and Business Development, Merck Serono International SA
Dr. Luca Bolliger, Director Business Development, Actelion Pharmaceuticals Ltd
Gwen Melincoff, VP Business Development, Shire Pharmaceuticals Inc.
Dr. Massimo Radaelli, President and CEO, Dompé International SA
   
Abstract:

The recent wave of consolidation across the European mid-size pharma companies raises a number of very important issues regarding their potential role as development partners for earlier stage companies. While some “new” companies are emerging with stronger portfolios and expertise in specialty markets, questions remain about their ability to compete and bid for assets going forward. At the same time, earlier stage companies, when considering their partnering options, will have to weigh the relative value of what may appear to be a more “committed” partner that may offer more downstream potential to the increasingly attractive deal economics offered by the larger pharma firms.  This session will examine the decision making process from both sides of the table – how mid-size pharma is approaching their in-licensing strategies going forward and how small-mid size biotech firms are evaluating their options when considering whether a mid-size pharma partner is a better option than selling out to the big guys.

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17:15-18:15
Bio-Drug Discovery – The Combination of White & Red Biotechnologies
Moderator:
Martin Austin, Managing Director,TransformRX
Panelists:
François Arcand, CEO, ERA Biotech, SA
Camille Burel, Industrial Biotech Project Administrator, EuropaBio
James C. Greenwood, President & CEO, Biotechnology Industry Organization (BIO)
Jack Grushcow, President, Linnaeus Plant Sciences Inc.
   
Abstract:

White, or industrial, Biotech is usually seen by the pharmaceutical industry as having a role only as a means of making savings through reductions in manufacturing costs. Given that cost of goods is a small component of overall drug costs, as yet, little attention has been paid to new technologies emerging from this new area.

However, White Biotechnology is making great strides not only in using bio-catalysis as a means for major reductions in the number of synthetic steps required to create complex compounds, it also produces novel compound structures leading to whole new libraries of products to screen both against known targets and those emerging from genomic studies of disease. This new and little explored area will be a major source of new products from Bio-Drug Discovery methods. The panel will discuss achievements to date and breaking developments in this exciting new field.

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13:30-18:15
THERAPEUTIC SESSIONS
13:30-14:30
Oncology
Moderator:
Vivian Lee , Managing Director, Aqua Partners LLC
Panelists:
Dr. Angeliki Kotsianti, Director, Global Clinical Technology, Pfizer Human Health Technologies
Dr. Neill MacKenzie, Senior VP, Business Development and Commercial Strategy, MediGene
David Muth, Executive VP and CBO, Avalon Pharmaceuticals
Prof. Giorgio Parmiani, Unit of Immuno/Biotherapy of Solid Tumors, Department of Oncology, San Raffaele Scientific Institute, Milano
 
Abstract:

Notwithstanding tremendous strides made in the laboratory, adoption of non-cytotoxics such as monoclonal antibodies and target-specific small molecules has taken much longer than early industry media hype suggested.  In 2005, cytotoxic agents still accounted for the bulk of the $20 billion cancer therapeutics market.  But by 2010, sales of drugs specific for genes, proteins, proteosomes and intracellular signaling pathways characteristic of cancer are expected to overtake that of conventional cytotoxic and antihormonal therapies in a market totaling an estimated $31 billion.       

This session will explore the link between cancer companies and the oncologists who are the ultimate adopters of their innovations.  What is the role of third party payor reimbursement?  What are the expectations and concerns facing clinicians and their patients in the field today?  How are these reconciled with development imperatives facing companies ranging from big pharma to emerging oncology specialty firms?  

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14:45-15:45
What is Next in the Antibody Space?
Moderator:
Mike Ward, Senior Editor, BioCentury Publications Inc.
Panelists:
Dr. Dominik Escher, CEO, ESBATech AG
Dr. Kevin Johnson, CEO, PanGenetics BV
Evert Kueppers, CEO, Pieris AG
Dr. Simon Moroney, CEO, MorphoSys AG
Prof. Jan G. J. van de Winkel, Executive VP & CSO, Genmab A/S
   
Abstract:

Antibodies have provided us with a successful therapeutic class of drugs and although there are drawbacks such as cost of production and patient administration, the market has grown rapidly in the recent years.

As technology has progressed, monoclonal antibodies were reengineered to chimeric, humanized and fully humanized versions reducing immune responses and increasing market potential. Traditional therapy areas for antibodies are oncology and autoimmune/inflammatory disorders, but infectious and cardiovascular diseases as well as ophthalmology also seem to be benefiting from the high level of innovation of antibody technology.

Copmanies are now turning their attention to the next generation of antibody-based therapeutics. Some pharma companies acquire antibody and antibody fragment companies, while others have signed deals worth potentially hundreds of millions of dollars.

This session will explore the opportunities and threats in the antibody space and look at the key players in this market. It will further examine which companies are innovators and what the key attributes of the next wave of antibody-like therapeutics will be.

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16:00-17:00
Infectious Diseases
Moderator:
Dr. Richard J. Hammel, Partner, Richard J. Hammel, IBC, Inc.
Panelists:
Dr. Cornelia Blaettchen, Head of Business Development & Licensing, Basilea Pharmaceutica Ltd.
John Hollway, VP, Business Development, Achaogen, Inc.
Dr. Praveen Tipirneni, Head of Corporate and Business Development, Cubist Pharmaceuticals
   
Abstract:

Infectious Diseases represent an area of clear unmet high medical need, not the least because it appears that no matter what new drugs are brought to the market, bacteria keep one step ahead!

Many current treatments can be effective, but with multiple side effects. Moreover, drug developers are also struggling with resistant strains and bacteria adapting to an ever-changing environment, an additional challenge to bringing effective drugs to the market.

Treatment of each condition has its own challenges, ranging from scientific to market dynamics. This panel will explore the specific challenges and hurdles that this therapeutic area is facing. Panelists will also try to identify market opportunities, emerging trends and promising treatment options and technologies.

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17:15-18:15
Central Nervous System (CNS)
Moderator:
Dr. Jesse Schulman, Director, Analysis & Research, Ferghana Europe LLP
Panelists:
Dr. Luca Benatti, CEO, Newron Pharmaceuticals SpA
Andy Brookes, Senior. Director, Business Development, Biogen Idec International GmbH

Dr. Lubor Gaal, Director, Licensing Europe, Bristol-Myers Squibb

Dr. John Kemp, Chief Research & Development Officer, Evotec AG
   
Abstract:

Disorders of the Central Nervous System (CNS) are many, varied and frequently severe, affecting a large portion of the population. These debilitating disorders include diseases such as epilepsy and migraine; degenerative conditions such as Parkinson's disease; and psychiatric disorders such as anxiety, bipolar disorder, depression, and schizophrenia. In addition, chronic pain is a neurological response to disease or injury; or it may have no readily apparent cause. Regardless of its origins, pain can have devastating effects on those suffering from it.

Progress towards finding a cure for CNS disorders has dramatically increased in the past years as our understanding of the brain and how disease affects it has improved. Nevertheless, there are still many conditions for which treatment choices are limited, and where drugs merely treat the symptoms and do not provide cures.

The complexity of the CNS makes it a challenging area of research but of course also a very rewarding space for the development of new drugs.

Where are the clear unmet medical needs in the CNS space? Which specific areas look most exciting today? What are the market opportunities and what are the specific threats?
This session will identify market dynamics and emerging technologies from a large pharma and biotech perspective.

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13:30-18:15
IN THE SPOTLIGHT
13:30-14:15
Country Seminar InvestInItaly
Italy: A Platform for Successful Growth and Innovative Business
The Seminar is an opportunity for the international business community to get acquainted with leading-edge Italian Biotech scientific achievements and latest industry developments. Come and explore a wide spectrum of collaborative prospects ranging from research to co-development programs and learn recent success stories pertaining to Italian and foreign collaborations.
   
Agenda:
13:30

Supporting business development of biotech investors in Italy
Roberto Spingardi – Head of Inward Investment, InvestInItaly

13:35

Industrial impacts pertaining to HTPS of molecules interfering with Embryonic Stem cell differentiation
Silvia Parisi – Senior Researcher, CEINGE – Biotecnologie Avanzate

13:45

Venturing on a new frontier: genetic vaccines for chronic diseases
Riccardo Cortese – President & CEO, OKAIROS

13:55 An Italian biotech success story
Luca Benatti – Managing Director & CEO, Newron Pharmaceuticals
14:05 The emerging biotechnology in Italy - The arrival of the bio renaissance
Byron Hewett – President & CEO, Immunicon Corporation
14:15

End of Session

   
14:30-15:45
Biotechnology in Italy 2007: A Financial and Strategic Analysis
BLOSSOM ASSOCIATI - ASSOBIOTEC REPORT
   
Welcome: Prof. Leonardo Santi, President of the National Committee for Biosafety, Biotechnology and Life Sciences at the  Presidency of the Council of Ministers


Chairman:
Dr. Roberto Gradnik, President of Assobiotec

Speakers:
Dr. Massimo Boriero, Board of Directors, Biotech Group of Farmindustria
Stefano Milani, Managing Director Blossom Associati, Contract Professor at the University of Pavia
Alberto Onetti, Professor at the Insubria State University of Varese, Director Research Centre for Health Care Management and Innovation (CrESIT)
Antonella Zucchella, Professor at the University of Pavia, VP Center for Innovation and Technology Transfer ITT" University of Pavia

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16:00-17:00
How to Tackle the financial Gap in Italy - Critical Factors and Experiences
Chairman:

Enrico Migliavacca, Member of the Board Camera di Commercio di Milano, President  Euro Info Centre Milano

Panelists:

Sara di Martino,